Vermehrt Anastomoseninsuffizienzen unter Diclofenac...

With leakage rates of around 3% after colonic resections and 10% after rectal resections and with mortality rates of up to 32%,1 2 anastomotic leakage remains a serious challenge for colorectal surgeons worldwide. In the past few years, there has been increased focus on the possible effect of non-steroidal anti-inflammatory drugs (NSAIDs) on the risk of anastomotic leakage.3 4 5 6 Retrospective studies have shown an association between anastomotic leakage and postoperative treatment with diclofenac and celecoxib, two NSAIDs that are predominantly cyclo-oxygenase-2 selective.3 4 5 Mehr